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Cannabis, also known as marijuana among other titles, is a carcinogenic medication from the Cannabis plant meant for medical or recreational use. The key psychoactive portion of cannabis is tetrahydrocannabinol (THC); among 483 known compounds in the plant, for example at least 65 additional cannabinoids. Cannabis may be used by smoking, vaporizing, in food, or as an infusion.

Cannabis is often employed because of its mental and physical effects, like a "high" or "stoned" sense, a general shift in perception, euphoria (heightened mood), and an increase in appetite. Onset of effects is within about 30 to 60 minutes eaten and once cooked, and minutes when eaten. They continue for between two and six hours. Short-term side effects may include a reduction in short-term memory, dry skin, impaired motor skills, red eyes, and feelings of paranoia or stress. Long-term side effects may include addiction, decreased mental ability in those who began as teens, and behavioral issues in children whose mothers used cannabis during pregnancy. Studies have found a strong relation between cannabis use and the risk of psychosis, though the cause-and-effect connection is debated.

Cannabis is mostly used recreationally or as a medicinal drug, though it may also be used for religious or spiritual purposes. In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the international population between the ages of 15 and 65). In 2015, 43% of Americans had used cannabis, which climbed to 51% in 2016. About 12% have used it at the last year, and 7.3% have used it in the last month. This makes it the most frequently used illegal drug both in the world and the United States.

The oldest recorded uses date from the 3rd millennium BC. Since the early 20th century, cannabis has been subject to legal limitations. The possession, use, and sale of cannabis is illegal in many countries of the world. Medical cannabis identifies the physician-recommended use of cannabis, which is happening in Canada, Belgium, Australia, the Netherlands, Germany, Spain, and 23 U.S. nations. Cannabis use started to become popular in the U.S. in the 1970s. Support for legalization has grown in the United States and several U.S. states have legalized medical or recreational use.

In December 2012, the U.S. state of Washington became the first state to formally legalize cannabis at a country law (Washington Initiative 502) (but still illegal by federal law), with the state of Colorado after close behind (Colorado Amendment 64). [200] On January 1, 2013, the first bud "club" for personal marijuana smoking (no buying or selling, nevertheless) was allowed for the first time in Colorado. The California Supreme Court determined in May 2013 that local authorities can prohibit medical marijuana dispensaries despite a state law in California that permits using cannabis for medical purposes. At least 180 cities across California have enacted bans in recent years.

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